Genetic material from the Zika virus has been discovered in the eyes. The finding which may explain why some patients develop eye disease, including a condition known as uveitis that can lead to permanent vision loss.
A new study describes the effect of Zika infection in the eyes of mouse fetuses, newborns, and adults. Researchers are now planning complementary studies in patients infected with the virus. “Our study suggests that the eye could be a reservoir for Zika virus,” says Michael S. Diamond, professor of medicine at Washington University School of Medicine in St. Louis. “We need to consider whether people with Zika have infectious virus in their eyes and how long it actually persists.”
Zika virus causes mild disease in most adults but can cause brain damage and death in fetuses. About a third of all babies infected in utero with Zika show eye disease such as inflammation of the optic nerve, retinal damage, or blindness after birth. In adults, Zika can cause conjunctivitis—redness and itchiness of the eyes—and, in rare cases, uveitis.
To determine what effect Zika infection has on the eye, researchers infected adult mice under the skin—similar to the way humans are infected by mosquitoes—and found live virus in the eyes seven days later. These observations confirm that Zika is able to travel to the eye. It is not yet known whether the virus typically makes that trip by crossing the blood-retina barrier that separates the eye from the bloodstream, traveling along the optic nerve that connects the brain and the eye, or some other route.
Eye infection raises the possibility that people could acquire Zika infection through contact with tears from infected people. The researchers found that the tears of infected mice contained Zika’s RNA—the genetic material from the virus—but not infectious virus, when tested 28 days after infection. “Even though we didn’t find live virus in mouse tears, that doesn’t mean that it couldn’t be infectious in humans,” says Jonathan J. Miner, an instructor in medicine and lead author of the study in the journal Cell Reports. “There could be a window of time when tears are highly infectious and people are coming in contact with it and able to spread it.”
The eye is an immune privileged site, meaning the immune system is less active there to avoid accidentally damaging sensitive tissues responsible for vision in the process of fighting infection. Consequently, infections sometimes persist in the eye after they have been cleared from the rest of the body. “We are planning studies in people to find out whether infectious virus persists in the cornea or other compartments of the eye, because that would have implications for corneal transplantation,” says Rajendra S. Apte, professor of ophthalmology and visual science. Other blood-borne viruses such as herpes simplex virus have been transmitted accidentally through corneal transplants.
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