Posts Tagged 'transplant research'

Antifibrotic Drugs Safe in Idiopathic Pulmonary Fibrosis Patients Undergoing Lung Transplant

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It is safe to administer antifibrotic drugs to patients with idiopathic pulmonary fibrosis, possibly reducing disease progression over time in those awaiting lung transplant, according to recent study results.

“With increasing use of antifibrotics following recent FDA approval, questions arise about their safety in idiopathic pulmonary fibrosis (IPF) patients undergoing lung transplant, yet safety data in this specific setting are currently lacking,” Isabelle Delanote, MD, from the department of respiratory disease at the University Hospitals Leuven in Belgium, and colleagues wrote. ...

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Research Suggests Kidney Donations Should Be Accepted From Older Patients

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Given the choice, most people on the kidney transplant wait list would choose an organ from a younger donor. But in some cases, receiving a lifesaving kidney from an older donor — alive or deceased — may be better than having no donor at all.

This new thinking is being driven, in part, by the shortage of kidneys available for transplant. According to the National Kidney Foundation, of the more than 121,000 people in the United States awaiting an organ transplant, ...

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Tumor Burden Limits Liver Transplant Feasibility for HCC

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Researchers have uncovered an upper limit in tumor burden after which there is a lower probability of successfully downstaging patients with hepatocellular carcinoma (HCC) for liver transplantation, according to findings presented at the 2016 AASLD Liver Meeting.

In the small prospective study, tumor burden was negatively predictive of successful downstaging for patients with HCC (HR, 0.87; P <.05). Overall, patients with a sum of number of tumors plus largest tumor diameter of 8 had a 68% probability of being downstaged to ...

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Fibrosis Risk High in Kids With Transplanted Livers

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Most children who received liver transplants developed mild fibrosis or cirrhosis within 10 years of undergoing the procedure, a researcher has said.

At 10-year biopsy, 68 (23%) of the 300 transplant recipients had normal or near normal histology, 142 (47%) had periportal or central fibrosis without bridging, 61 (20%) had bridging fibrosis, and 29 (10%) had cirrhosis, according to Jeremy Rajanayagam, MBBS, of the Royal Children’s Hospital in Melbourne, Australia.

While the grafts usually last 20 years, patients who develop cirrhosis are ...

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Lab-Grown Mini Lungs Successfully Transplanted Into Mice

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Researchers at the University of Michigan have transplanted lab-grown mini lungs into immunosuppressed mice where the structures were able to survive, grow and mature.

“In many ways, the transplanted mini lungs were indistinguishable from human adult tissue,” says senior study author Jason Spence, Ph.D., associate professor in the Department of Internal Medicine and the Department of Cell and Developmental Biology at the U-M Medical School.

The findings were published in eLife and described by authors as a potential new tool to study ...

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Kidney Transplants Seen to Improve Aspects of Cardiac Health in CKD Patients

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Kidney disease patients who undergo a transplant show a degree of improved cardiac health afterward, researchers reported, highlighting the known, dynamic interaction between the kidneys and the heart.

For the study, “Improved Left Ventricular Structure and Function After Successful Kidney Transplantation,” published in the journal Kidney and Blood Pressure Research, a research team from Germany evaluated 31 patients with chronic kidney disease (CKD) who had received a kidney transplant.

The team performed medical examinations, laboratory tests and echocardiography before and after surgery. ...

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Phase 1 Trial of Triplex Vaccine for Control of Cytomegalovirus

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City of Hope, a world-renowned independent research and cancer treatment center, and Helocyte, Inc., a majority-owned subsidiary of Fortress Biotech, Inc. (NASDAQ:FBIO), announced today that data from the Phase 1 trial of Helocyte’s Triplex vaccine were published online this month in Blood, the journal of the American Society of Hematology.

The vaccine is initially being developed for control of cytomegalovirus (CMV) in allogeneic hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients. In the Phase 1 study, Triplex was ...

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Coffee Delays Liver Disease Progression, Extends Survival Post-Transplant

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Drinking at least 200 mL coffee a day may stave off the advancement of alcoholic liver disease and some cases of primary sclerosing cholangitis in patients with end-stage liver disease awaiting liver transplant, according to recent published findings. In addition, coffee consumption may increase survival post-transplant.

“The limitation of donated organs highlights the importance of identifying modifiable factors that can aid in the management of patients awaiting liver transplantation and help to optimize outcome after liver transplantation,” Kilian Friedrich, MD, of ...

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San Diego Company Aims To Create 3-D Printed Liver Transplant Patches

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One in five Americans in need of a liver transplant dies on the wait list. San Diego-based Organovo hopes to change that by creating transplantable liver tissue in the lab.

The company’s 3-D printed organ tissue is already being used by pharmaceutical companies to test new drugs. And cosmetics giant L’Oreal is using Organovo’s 3-D printed skin to test beauty products. But on Tuesday, the company announced new plans to develop 3-D printed liver tissue for direct transplantation into people.

“People have thought ...

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Growing Bio-Lungs for Organ Donation?

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The idea of growing replacement lungs, grown from the cells of the person who needs them, in a laboratory and then transferring these into the patient falls within the field of regenerative medicine.

This could come about by using a patient’s own cells to create new organs in decellularized scaffolds. To achieve this a device would be required to hold the lungs and allow them to grow.

This is the basis of studies conducted at Yale University. The study to date has ...

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