Posts Tagged 'rejection'

Could Blood Test Predict Lung Transplant Rejection?

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Note: Check out our recent webinar on this topic: “Detecting Rejection Without Biopsies: Are We There Yet?”

A novel blood-based biomarker of lung transplant dysfunction in newly transplanted lungs could help identify patients at high risk for chronic rejection without a lung biopsy, researchers reported.

In what was characterized as a proof-of-concept study, researchers from the National Heart, Lung, and Blood Institute (NHLBI), Johns Hopkins School of Medicine, and several other institutions described how donor-derived cell-free DNA (%ddcfDNA) characterized “post-transplantation ...

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New intervention aims to improve treatment adherence among teen kidney transplant recipients

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Learning to become self-sufficient and responsible is part of life’s journey through the teen and young adult years. Mistakes are often made, and lessons are learned. However, for young kidney-graft patients, any mistake or failure in keeping to their strict immunosuppressive therapy can lead to tragic results. In fact, low-adherence to medication remains a major contributor to the high level of organ rejection in this age group.

Transplant specialists and researchers from eight leading pediatric medical centers across Canada and the ...

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Man becomes first patient to receive a second face transplant

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Twelve years ago, a team of surgeons in France successfully completed the first-ever face transplant procedure. Unfortunately, seven years after the history-making surgery, the patient’s body rejected the transplant.

Since the rejection occurred, the patient has been living without a suitable alternative. In a risky move, surgeons decided to attempt to transplant a second face, this time from a different donor. It’s still too soon to say whether or not this transplant will be accepted, but the surgery itself was successful.

Rejection is likely ...

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Researchers discover indicator of lung transplant rejection

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Research by scientists at Dignity Health St. Joseph’s Hospital and Medical Center’s Norton Thoracic Institute was published in the July 12, 2017 issue of Science Translational Medicine titled, “Zbtb7a induction in alveolar macrophages is implicated in anti-HLA-mediated lung allograft rejection.”

This research was conducted at the laboratories of Thalachallour Mohanakumar, PhD and Deepak Nayak’s PhD at the Norton Thoracic Institute in Phoenix, Ariz. The labs are dedicated to the understanding of immunologic reactions leading to graft rejection following human lung transplantation.

Lung transplantation, where diseased lungs ...

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Lung “Filtering” Technique May Reduce Transplant Rejection

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At the University of Manchester, researchers have partnered with the University of Lund in Sweden and tested the use of ex-vivo lung perfusion to recondition poorly functioning lungs and remove donor white blood cells in the hopes to reduce the risk of rejection and thereby increasing the number of lungs available for transplant.

Donor white blood cells can be harmful to the recipient and can cause acute rejection of the transplanted organ. Ex-vivo lung perfusion (EVLP) allows for the lungs to ...

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