Posts Tagged 'organ donation and transplantation alliance'

Heat therapy may aid treatment of cancer, organ transplants and autoimmune disease

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Heat therapy may be a promising treatment in the fight against cancer, autoimmune problems and efforts to avoid organ rejection in transplant patients, according to researchers at the University of Kentucky. The research team exposed colorectal cancer cells and T-cells—immune cells that fight disease—to temperatures lower (hypothermic) and higher (hyperthermic) than normal body temperatures. They observed the effects of these temperature changes on the energy production (bioenergetics) in both cell types. They will present their findings at the American Physiological ...

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Donor intervention strategies have potential to increase number of transplantable organs

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In a recent article published in The Hastings Center Report, the authors assert that “interventional research on deceased organ donors and donor organs prior to transplant holds the promise of reducing the number of patients who die waiting for an organ by expanding the pool of transplantable organs and improving transplant outcomes.” The authors posit, “one of the key challenges researchers face is an assumption that someone who receives an organ that was part of an interventional research ...

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Nanoparticles “trick” body into accepting organ transplants

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Using nanoparticles, Yale researchers have developed a drug-delivery system that could reduce organ transplant complications by hiding the donated tissue from the recipient’s immune system.

About 25,000 organ transplants are performed in the U.S. each year. Despite significant advances in the field, short-term and long-term organ rejection still poses a risk (rejection rates vary depending on the type of organ). The risk of rejection is even higher when the donor is deceased, due to organ damage.

T cells, the white blood cells ...

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Novel procedure improves kidney transplant success

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A new treatment might open the door for more patients with advanced kidney disease to get a transplant, a preliminary study suggests.

Of the 100,000-plus Americans waiting for a donor kidney, about one-third are “sensitized,” said Dr. Robert Montgomery, director of the Transplant Institute at NYU Langone in New York City.

Those patients face a tough situation: They harbor immune system antibodies that are primed to attack a donor organ.

The antibodies can form when a person is ...

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Liver transplant patients benefit from moderate, high intensity exercise

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Combined resistance and aerobic training at moderate to high intensity improved aerobic capacity, maximal strength and health-related quality of life in liver transplant patients, according to a recently published study.

“An adequate recovery together with an improvement in the patient fitness and indirect understanding of the relevance of exercise in [health-related quality of life] may result in the long-term in a reduced incidence of metabolic complications,” Diego Moya-Nájera, MsC, from the University of Valencia, Spain, and colleagues wrote. “Indeed, diseases associated with metabolic ...

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Pros and Cons: Infecting patients with hepatitis C to save their lives

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Around the country, physicians have begun transplanting HIV-positive organs into HIV-positive patients, thanks to the reversal in 2013 of a 1998 law that banned their use. And it has become standard for transplant centers to give hep C–positive organs to patients who already have a hep C infection. Now doctors have crossed a medical threshold—and an ethical one: giving infected kidneys and livers to people who had no trace of hep C to help them get an organ ...

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Engineered liver tissue expands after transplant

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Many diseases, including cirrhosis and hepatitis, can lead to liver failure. More than 17,000 Americans suffering from these diseases are now waiting for liver transplants, but significantly fewer livers are available.

To help address that shortage, researchers at MIT, Rockefeller University, and Boston University have developed a new way to engineer liver tissue, by organizing tiny subunits that contain three types of cells embedded into a biodegradable tissue scaffold. In a study of mice with damaged livers, the researchers found that ...

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Education Corner – Supporting Children in Grief & through Donation

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Supporting Children in Grief & through Donation

Supporting children through grief can be a daunting and cause anxiety. Understanding the developmental stages and how to focus the communication can be helpful.

Pace yourself, pause the conversation, and know you can return to this conversation over time.

Developmental Stages & Ages

Birth – 2 Years

  • No understanding of death
  • No words for feelings
  • Notices changes in family emotions and routines

How to help: Meet needs, maintain routines, offer physical contact

3 – 5 Years

  • No ...
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Yale’s Center for Living Organ Donors brings donors together, provides lifelong health monitoring

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The last few times Connecticut had snowstorms, Matt Ragaini worked marathon hours plowing and dispatching plows for the city of Bristol. His wife, Jen, marveled at his stamina. Just two years before, the couple were lying in adjoining operating rooms so that doctors could give Matt a section of Jen’s liver. The hope was that this would cure a chronic liver disease called primary sclerosing cholangitis that had stolen Matt’s energy and could have killed him. Before the ...

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A New Solution for Immunosuppressants – Limb Transplant Gel?

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Through a highly collaborative effort, the problem of immunosuppressive therapy and long-term impact on the recipient of a limb or face transplant, led to the development of a new solution: transplant gel.  This collaboration occurred between Dr. Jeff Karp, Associate Professor of Medicine at Brigham and Women’s Hospital in Boston, Robert Riebens from Switzerland, and Praveen Kumar Vemula, who was post-doc in Dr. Karp’s lab and now is faculty in India,

The transplant gel is a hydrogel based technology that can deliver ...

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