Liver transplant patients gain survival benefits by accepting organs from older donors, new research shows

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BOSTON: Patients with advanced liver disease who accept liver transplants donated by people over age 70 reduce their long-term risk of death significantly compared with similar patients who decline the same offer. That survival benefit remains across the range of Model for End-stage Liver Disease (MELD) scores, according to new research findings presented at the American College of Surgeons Clinical Congress 2018.

Transplant surgeons predominately use livers from donors under age 70 in order to avoid risks such as graft failure ...

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In some patients, hepatitis C best treated after transplant

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Direct-acting antiviral drugs can eradicate the hepatitis C virus, even in patients with advanced liver decompensation. But their outcomes may be better if treatment occurs after transplant, according to a recent study looking at this issue.

The goal of the study was to determine when life expectancy was improved with DAA treatment, before or after liver transplant. One reason these may differ is that the trade-off for improved liver function with early treatment is the risk for delay—or even delisting for ...

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Should Factors Such as Cost and Frailty be Considered in Transplant with MELD 40 or Higher?

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Two experts at The Liver Meeting 2016 debated if and when transplant would be futile or not in patients with a MELD score higher than 40, and both agreed more than just MELD must be considered.

“Mortality should not be the only endpoint,” Abraham Shaked, MD, PhD, from the University of Pennsylvania, said during his argument that transplant in the high MELD setting is futile. “We should minimize the economic burden on the health care system, think about where these patients ...

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