Posts Tagged 'lung transplant'

Could Blood Test Predict Lung Transplant Rejection?

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Note: Check out our recent webinar on this topic: “Detecting Rejection Without Biopsies: Are We There Yet?”

A novel blood-based biomarker of lung transplant dysfunction in newly transplanted lungs could help identify patients at high risk for chronic rejection without a lung biopsy, researchers reported.

In what was characterized as a proof-of-concept study, researchers from the National Heart, Lung, and Blood Institute (NHLBI), Johns Hopkins School of Medicine, and several other institutions described how donor-derived cell-free DNA (%ddcfDNA) characterized “post-transplantation ...

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Patient Develops Donor’s Peanut Allergy After Lung Transplant

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A 68-year-old woman, who had never had a peanut allergy, had a severe allergic reaction to a peanut butter and jelly sandwich, according to a recent report of her case, which was published in August in the journal Transplantation Proceedings. But someone else did have a peanut allergy, it turned out: her lung donor.

It’s a very rare occurrence for lung transplant recipients to acquire a food allergy from a donor organ, said lead case report author Dr. Mazen Odish, a ...

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Hepatitis C positive lungs safely transplanted to patients

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Lungs from donors who had hepatitis C have been successfully transplanted into 10 patients at Toronto General Hospital (TG).

All patients have recovered from their transplant surgery. Eight of them have already tested negative for the virus and the last two patients have recently started taking the drug regimen.

The transplants are part of a clinical trial that is the first to assess the safety of transplanting hepatitis positive organs to non-infected patients using the ex vivo technology. Developed at TG in 2008, the Toronto Ex Vivo ...

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Study shows promise for donor lung preservation device

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A landmark study conducted by a team of researchers found that a portable perfusion device was associated with less primary graft dysfunction, a syndrome of acute lung injury that occurs within the first 72 hours after transplantation, compared to standard ice preservation of a donor lung during transportation from donor to transplant patient. Their work was published recently in The Lancet Respiratory Medicine.

“This was the largest trial of its kind in the history of organ preservation and marks ...

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UVA launches human testing of lung transplant drug

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In the culmination of decades of research at the University of Virginia Health System, doctors have begun human testing of a drug they hope will one day save many lives among lung transplant recipients.

The drug, regadenoson, is already commonly used to image cardiac patients’ hearts. But the UVA research suggests it could be put to another, lifesaving purpose: battling ischemia reperfusion injury, in which tissue is damaged by the restoration of blood flow after it has been cut off.

The principal ...

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Researchers discover indicator of lung transplant rejection

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Research by scientists at Dignity Health St. Joseph’s Hospital and Medical Center’s Norton Thoracic Institute was published in the July 12, 2017 issue of Science Translational Medicine titled, “Zbtb7a induction in alveolar macrophages is implicated in anti-HLA-mediated lung allograft rejection.”

This research was conducted at the laboratories of Thalachallour Mohanakumar, PhD and Deepak Nayak’s PhD at the Norton Thoracic Institute in Phoenix, Ariz. The labs are dedicated to the understanding of immunologic reactions leading to graft rejection following human lung transplantation.

Lung transplantation, where diseased lungs ...

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New method rescues donor organs to save lives

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Researchers have — for the first time — maintained a fully functional lung outside the body for several days. They designed the cross-circulation platform that maintained the viability and function of the donor lung and the stability of the recipient over 36-56 hours, used the advanced support system to fully recover the functionality of lungs injured by ischemia and made them suitable for transplant.

Read more at https://www.sciencedaily.com/releases/2017/03/170306114242.htm

 

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Antifibrotic Drugs Safe in Idiopathic Pulmonary Fibrosis Patients Undergoing Lung Transplant

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It is safe to administer antifibrotic drugs to patients with idiopathic pulmonary fibrosis, possibly reducing disease progression over time in those awaiting lung transplant, according to recent study results.

“With increasing use of antifibrotics following recent FDA approval, questions arise about their safety in idiopathic pulmonary fibrosis (IPF) patients undergoing lung transplant, yet safety data in this specific setting are currently lacking,” Isabelle Delanote, MD, from the department of respiratory disease at the University Hospitals Leuven in Belgium, and colleagues wrote. ...

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Dignity Health St. Joe’s Marks 500th Lung Transplant

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Early on the morning of Oct. 25, 2016, Robin Ritchie, 67, made her way into St Joseph’s Hospital. She was a very sick woman. Eighteen months earlier, her doctor told her in no uncertain terms, “I think you’re one hospital stay with pneumonia, or something like that, away from dying,” Ritchie recalled while fighting back tears.

The retired, middle school teacher had been battling emphysema and pulmonary hypertension for years. And now she was told her options were limited, except for ...

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Growing Bio-Lungs for Organ Donation?

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The idea of growing replacement lungs, grown from the cells of the person who needs them, in a laboratory and then transferring these into the patient falls within the field of regenerative medicine.

This could come about by using a patient’s own cells to create new organs in decellularized scaffolds. To achieve this a device would be required to hold the lungs and allow them to grow.

This is the basis of studies conducted at Yale University. The study to date has ...

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