Posts Tagged 'Hepatitis C'

Hepatitis C not a barrier for organ transplantation, study finds

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From NPR science correspondent Richard Harris:

Donated organs from people who were infected with the hepatitis C virus can be safely transplanted, according to the latest in a line of studies that are building a case for using these organs.

Typically, these organs have been discarded because of concerns about spreading the viral infection. But a study of heart and lung transplants published Wednesday by the New England Journal of Medicine finds that new antiviral drugs are so effective that the recipients ...

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Hepatitis C-positive Heart Transplants: Safer After All?

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As of July 5, 2018, there are 3,960 people in the United States on the waitlist for a heart transplant. That’s only a fraction of the 114,554 people who need organ transplants. There is a great need for organ donations, and physicians at the University of Washington Medical Center have initiated a protocol to help with that.

The UW heart transplant team, led by Dr. Jason Smith, the associate surgical director of heart transplantation and a cardiac surgeon, plans to transplant hearts from ...

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Hepatitis C positive lungs safely transplanted to patients

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Lungs from donors who had hepatitis C have been successfully transplanted into 10 patients at Toronto General Hospital (TG).

All patients have recovered from their transplant surgery. Eight of them have already tested negative for the virus and the last two patients have recently started taking the drug regimen.

The transplants are part of a clinical trial that is the first to assess the safety of transplanting hepatitis positive organs to non-infected patients using the ex vivo technology. Developed at TG in 2008, the Toronto Ex Vivo ...

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Education Corner – Hepatitis C Positive Organ Donors – Is That Possible?

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Hepatitis C Positive Organ Donors – Is That Possible? – (Download PDF Version)

About the Hepatitis C Virus (HCV)

  • RNA (ribonucleic acid) viral infection
  • Causes liver inflammation and can cause severe liver damage
  • Spread through contaminated blood
  • Half of people infected with HCV are asymptomatic and do not know they are infected

Symptoms Can Include:

  • Almost always only ...
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DAAs prove effective for HCV-infected heart transplant patients

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Direct-acting antiviral (DAA) drugs proved safe and effective for hepatitis C (HCV) patients who had undergone heart transplants, according to new research.

Jia-Horng Kao, MD, PhD, FAASLD, and a team from the National Taiwan University Hospital in Taipei, found that 12 individuals given sofosbuvir combined with ledipasvir (Harvoni) or sofosbuvir (Sovaldi) combined with daclatasvir (Daklinza) achieved a sustained virologic response rate of 100% after 12 weeks.

Interferon-free DAAs have shown excellent efficacy and safety for ordinary patients with chronic HCV infection, the researchers ...

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In some patients, hepatitis C best treated after transplant

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Direct-acting antiviral drugs can eradicate the hepatitis C virus, even in patients with advanced liver decompensation. But their outcomes may be better if treatment occurs after transplant, according to a recent study looking at this issue.

The goal of the study was to determine when life expectancy was improved with DAA treatment, before or after liver transplant. One reason these may differ is that the trade-off for improved liver function with early treatment is the risk for delay—or even delisting for ...

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Pros and Cons: Infecting patients with hepatitis C to save their lives

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Around the country, physicians have begun transplanting HIV-positive organs into HIV-positive patients, thanks to the reversal in 2013 of a 1998 law that banned their use. And it has become standard for transplant centers to give hep C–positive organs to patients who already have a hep C infection. Now doctors have crossed a medical threshold—and an ethical one: giving infected kidneys and livers to people who had no trace of hep C to help them get an organ ...

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HCV drugs may slash wait times for transplants

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Imagine this: You’re treating a patient with end-stage renal disease (ESRD) who has been on the kidney transplant list for almost a year. That’s not a surprising delay; more than 100,000 people are on the waiting list nationwide, and the median wait time is now over 3.5 years. So your patient probably has at least two more years to wait—years of dialysis in which he might become too sick to receive that transplant or die before it becomes available. (More ...

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Intermountain Among First in U.S. to Use Diseased Livers for Transplant

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MURRAY — Lorenzo Swank was dying in his 20s.

Diagnosed with a chronic liver disease called primary sclerosing cholangitis in 2010, the Salt Lake man was added to the liver transplant waitlist in 2013. As bile built up in his liver, Swank began to lose liver function. By May, he was close to dying. And yet, there was no word that a liver for Swank was coming anytime soon.

That’s when doctors at Intermountain Medical Center approached him with an unusual idea: ...

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First Clinical Trial Transplants Hepatitis C-Infected Kidneys

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Patients who need a kidney transplant may have new hope, through an innovative Penn Medicine clinical trial using kidneys from deceased donors who had the Hepatitis C virus (HCV). The first study participant received a kidney transplant in July 2016, and after being treated with a full regimen of Zepatier – a recently-approved oral medication prescribed to eradicate HCV – her doctors announced today that there is no evidence of the virus in her blood. Irma Hendricks of East Stroudsburg, ...

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