Kidney transplant increases survival in GPA patients

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Patients with granulomatosis with polyangiitis (GPA, formerly known as Wegener’s) who develop end-stage renal disease (ESRD) and undergo a kidney transplant have a significantly reduced risk of death, a national study found.

Among patients with GPA who were wait-listed for renal transplantation from 1995 to 2014, those who received the transplant had a 70% reduction in all-cause mortality (RR 0.30, 95% CI 0.25 to 0.36), according to Zachary S. Wallace, MD, and colleagues from Harvard Medical School and Massachusetts General Hospital in Boston.

This decrease in mortality risk was largely driven by a “dramatic” 90% reduction in cardiovascular mortality (RR 0.10, 95% CI 0.06 to 0.16), the researchers reported in Annals of the Rheumatic Diseases.

GPA is a small-vessel vasculitis characterized by the presence of antineutrophil cytoplasmic antibodies. Up to 70% of afflicted individuals develop renal disease — usually glomerulonephritis — and 20% to 25% of these progress to ESRD.

Continue reading at https://www.medpagetoday.com/rheumatology/generalrheumatology/72889

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Corey joins The Alliance with more than ten years of experience in corporate and non-profit fields, having worked in Communications for The Walt Disney Company and most recently, Public Relations for TransLife, the OPO serving Central Florida. He has also been an active board member of Donate Life Florida, serving as state team leader for the Driver License Outreach taskforce. Corey holds a Bachelor of Arts in Communication and Information Sciences from The University of Alabama. In his spare time, he is an avid music and theater enthusiast, enjoys traveling, Crimson Tide Football and serving on the board for several local charities in the Orlando area.
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