Patients with granulomatosis with polyangiitis (GPA, formerly known as Wegener’s) who develop end-stage renal disease (ESRD) and undergo a kidney transplant have a significantly reduced risk of death, a national study found.
Among patients with GPA who were wait-listed for renal transplantation from 1995 to 2014, those who received the transplant had a 70% reduction in all-cause mortality (RR 0.30, 95% CI 0.25 to 0.36), according to Zachary S. Wallace, MD, and colleagues from Harvard Medical School and Massachusetts General Hospital in Boston.
This decrease in mortality risk was largely driven by a “dramatic” 90% reduction in cardiovascular mortality (RR 0.10, 95% CI 0.06 to 0.16), the researchers reported in Annals of the Rheumatic Diseases.
GPA is a small-vessel vasculitis characterized by the presence of antineutrophil cytoplasmic antibodies. Up to 70% of afflicted individuals develop renal disease — usually glomerulonephritis — and 20% to 25% of these progress to ESRD.
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