A high-dose influenza vaccine is preferable to a standard-dose vaccine in adult solid organ transplant recipients, according to study findings presented at IDWeek.
Yoichiro Natori, MD, clinical fellow of transplant infectious diseases at the University Health Network, University of Toronto, summarized results showing that a high-dose influenza vaccine (Fluzone High-Dose, Sanofi Pasteur; HD) demonstrated “significantly better immunogenicity” when compared with a standard-dose vaccine (Fluviral, GlaxoSmithKline; SD) in adult solid organ transplant recipients.
“Transplant recipients are on lifelong immunosuppression and a particularly vulnerable population when it comes to the complications of influenza,” study author Deepali Kumar, MD, MSc, FRCPC, associate professor of medicine at the University of Toronto and staff physician in the multi-organ transplant program at University Health Network, told Infectious Disease News. “Although it is recommended and widely used in this group, the standard-dose influenza vaccine is well-known to be suboptimal. In fact, influenza infection despite being vaccinated is quite common in this population.”
Earlier this year, researchers in Spain reported that administering a second dose of influenza vaccine 5 weeks after the initial vaccination made them more effective among solid organ transplant recipients.
Kumar said HD vaccination is not yet standard of care for solid organ transplant recipients, but based on the results of their study, they hope to offer it this upcoming influenza season.
“This is first time that we have found an influenza vaccine that has greater immunogenicity compared to the standard-dose vaccine in an immunosuppressed population,” she said. “We believe that based on our findings, the high-dose influenza vaccine may be a better option for immunosuppressed transplant patients. Also, given our results, the high-dose vaccine should be studied further in other immunosuppressed populations.”Share