First US Clinical Trial Begins – Uterus Transplant

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The first clinical trial of uterus transplantation in the United States has begun at Cleveland Clinic in Ohio, where the process of selecting women to participate in the study is now under way. The ground-breaking study will include 10 women with uterine factor infertility (UFI), a condition in which a woman was born without a uterus, has lost her uterus, or has a uterus that no longer functions. For these women, traditional pregnancy is not possible.

Uterus transplantation may enable women with UFI to become pregnant and give birth. “Women who are coping with UFI have few existing options,” Tommaso Falcone, MD, Ob/Gyn & Women’s Health Institute Chair, said in an article published in Health Essentials, a Cleveland Clinic publication, on November 12. “Although adoption and surrogacy provide opportunities for parenthood, both pose logistical challenges and may not be acceptable due to personal, cultural or legal reasons.”

“We are proud to have received approval to move forward with this novel study. It is a product of many years of research, the expertise of our medical teams and the support of our organization,” Dr Falcone said. The first two international attempts at uterus transplantation failed, largely because of organ rejection during pregnancy. Cleveland Clinic participated in research that eventually enabled a research team at the University of Gothenburg in Sweden to manage the mild organ rejection that sometimes occurs. The Swedish research team accomplished its first birth in September 2014 and has performed a total of nine uterus transplants that have resulted in five pregnancies and four live births.

Read full article at http://www.medscape.com/viewarticle/854649

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