Consensus Conference on Primary Graft Dysfunction post Heart Transplantation Report

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A report on the consensus conference on primary graft dysfunction (PGD) after heart transplantation, that was held at the 33rd annual International Society of Heart and Lung Transplant (ISHLT) meeting, has been published by the American College of Cardiology.

The consensus conference saw 71 participants from 42 different heart transplant centers from North America, Asia, Europe, and Australia. The online survey collecting PGD rates was completed by 47 heart transplant centers from around the world and represented almost ten thousand patient experiences. Resulting from the consensus conference were guidelines for improved definition, diagnosis, and management of patients with PGD.

The messages to highlight from this conference are:

  • A clear definition of PGD is essential for future monitoring of the care and outcomes of patients with PGD and for the creation of a future registries of these activities. PGD was defined as “left, right, or biventricular dysfunction in the absence of a discernible cause, including hyperacute rejection, pulmonary hypertension, or a known surgical complication.”
  • A severity scale of PGD allows for the determination of effects of therapies or risk factors among patients with a comparable degree of PGD.
  • The agreement of the validity of the option for re-transplantation for patients with PGD who have no recovery with supportive care and have preserved extracardiac organ function.

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