Cleveland Clinic Performs First U.S. Uterus Transplant

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(CNN) A team of surgeons at the Cleveland Clinic performed the first uterus transplant in the United States this week. A 26-year-old woman received the new womb in a nine-hour operation, the hospital said in a statement. She was reported in stable condition Thursday. The transplanted uterus came from a deceased organ donor.

Clinical trial
The Cleveland Clinic announced a research study in November in which it would perform uterus transplants on 10 women with uterine factor infertility.
UFI is a condition where a woman cannot carry a pregnancy because she was born without a uterus, has lost her uterus, or has a uterus that no longer functions. It’s an irreversible condition affecting 3% to 5% of women worldwide.
“Women who are coping with UFI have few existing options,” Tommaso Falcone, chairman of the Department of Obstetrics-Gynecology at Cleveland Clinic, said when the clinical trial was announced. “Although adoption and surrogacy provide opportunities for parenthood, both pose logistical challenges and may not be acceptable due to personal, cultural or legal reasons.”

A route to pregnancy
The transplant is one of many steps in a complex process.
Before it takes place, the woman’s eggs are harvested, fertilized and frozen for implantation later in the new uterus.
These are some of the other steps, according to the Cleveland Clinic:
— Over 12 months, the transplanted uterus fully heals.
— One year after transplant, the frozen embryos are then thawed and implanted, one at a time, into the patient until she becomes pregnant.
— During her pregnancy, she takes anti-rejection drugs.
— She is monitored by a high-risk obstetrics team throughout pregnancy and delivery.
— She has a monthly cervical biopsy to check for organ rejection.
— The baby is delivered by cesarean section.
— After one to two babies, she has a hysterectomy to remove the transplanted uterus.
— Her anti-rejection drugs are stopped after the hysterectomy.


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