Hepatitis C positive lungs safely transplanted to patients

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Lungs from donors who had hepatitis C have been successfully transplanted into 10 patients at Toronto General Hospital (TG).

All patients have recovered from their transplant surgery. Eight of them have already tested negative for the virus and the last two patients have recently started taking the drug regimen.

The transplants are part of a clinical trial that is the first to assess the safety of transplanting hepatitis positive organs to non-infected patients using the ex vivo technology. Developed at TG in 2008, the Toronto Ex Vivo ...

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Education Corner – Hepatitis C Positive Organ Donors – Is That Possible?

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Hepatitis C Positive Organ Donors – Is That Possible? – (Download PDF Version)

About the Hepatitis C Virus (HCV)

  • RNA (ribonucleic acid) viral infection
  • Causes liver inflammation and can cause severe liver damage
  • Spread through contaminated blood
  • Half of people infected with HCV are asymptomatic and do not know they are infected

Symptoms Can Include:

  • Almost always only ...
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Army doctors transplant new ear from soldier’s arm

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An Army soldier who lost her ear received a revolutionary transplant in which doctors grew her a brand new ear on the patient’s own arm.

Plastic surgeons at William Beaumont Army Medical Center (WBAMC) in El Paso successfully transplanted the organ onto Shamika Burrage after the Army Private lost her left ear in a one-car accident while on leave in 2016. Instead of finding a donor, surgeons took cartilage from Burrage’s ribs and carved it into the shape ...

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Kidney transplant increases survival in GPA patients

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Patients with granulomatosis with polyangiitis (GPA, formerly known as Wegener’s) who develop end-stage renal disease (ESRD) and undergo a kidney transplant have a significantly reduced risk of death, a national study found.

Among patients with GPA who were wait-listed for renal transplantation from 1995 to 2014, those who received the transplant had a 70% reduction in all-cause mortality (RR 0.30, 95% CI 0.25 to 0.36), according to Zachary S. Wallace, MD, and colleagues from Harvard Medical School and Massachusetts General Hospital ...

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NIH clinical trial to track outcomes of kidney transplantation from HIV-positive donors to HIV-positive recipients

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The first large-scale clinical trial to study kidney transplantations between people with HIV has begun at clinical centers across the United States. The HOPE in Action Multicenter Kidney Study will determine the safety of this practice by evaluating kidney recipients for potential transplant-related and HIV-related complications following surgery. The study is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

While organ transplants between donors and recipients with HIV have been successfully ...

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Education Corner – Serology Testing for Deceased Organ Donors

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SEROLOGY TESTING FOR DECEASED ORGAN DONORS
(Download PDF Version)

Serology Testing Basics

Why test donors? Donor screening for infectious diseases helps prevent unintentional disease transmission to recipients. It is also used to anticipate potential recipient infection and treat the recipient post-transplant.

What is tested? Testing kits are used to detect antigens, antibodies, or ...

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Doctors perform world’s first full penis-and-scrotum transplant

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Doctors at Johns Hopkins Medicine performed the world’s first complete penis-and-scrotum transplant.

The 14-hour operation, which took place on March 26, involved a team of nine plastic surgeons and two urological surgeons, according to a statement from Johns Hopkins Medicine. The surgeons transplanted the entire penis, scrotum (without the testicles) and a part of the abdominal wall from a deceased donor to the recipient, a veteran who was wounded in Afghanistan.

The transplant was the result of more than five years of ...

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Study shows promise for donor lung preservation device

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A landmark study conducted by a team of researchers found that a portable perfusion device was associated with less primary graft dysfunction, a syndrome of acute lung injury that occurs within the first 72 hours after transplantation, compared to standard ice preservation of a donor lung during transportation from donor to transplant patient. Their work was published recently in The Lancet Respiratory Medicine.

“This was the largest trial of its kind in the history of organ preservation and marks ...

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Keeping donated livers warm could improve transplants

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Surgeons pack donated organs on ice while racing them to transplant patients but it may be time for a warmer approach. British researchers said Wednesday that keeping at least some livers at body temperature instead may work better.

The livers keep functioning until they’re transplanted thanks to a machine that pumps them full of blood and nutrients. It’s a life-support system for the organs and similar machines are being explored for lung and heart transplants, too.

The transplant community isn’t ditching affordable ...

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Researchers examine barriers to organ donation and possible remedies

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Two new collaborative papers by UC Merced Economics Professor Kurt Schnier reveal that increasing the incentives and eliminating barriers for donors — both living and deceased — would greatly improve other people’s chances of receiving life-saving transplants.

One collaboration, involving a transplant surgeon and two other economists, focused on increasing people’s willingness to be deceased organ donors. The other collaboration, involving two transplant surgeons and a public health researcher, investigated a government policy targeted at increasing living organ donation by lowering donor-related costs.

Both ...

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