Innovation

Fluorescing urine signals organ transplant rejection, could replace needle biopsies

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Glowing urine may replace the biopsy needle: In detecting organ transplant rejection, a new nanoparticle has proven much faster and more thorough in the lab than a biopsy. When T cells mount their first attack on the organ’s cells, the nanoparticle sends an alarm signal into the urine that makes it fluoresce.

Too often, it’s only after a transplanted organ has sustained serious damage that a biopsy reveals the organ is in rejection. A new screening method using sensor particles and ...

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Could Blood Test Predict Lung Transplant Rejection?

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Note: Check out our recent webinar on this topic: “Detecting Rejection Without Biopsies: Are We There Yet?”

A novel blood-based biomarker of lung transplant dysfunction in newly transplanted lungs could help identify patients at high risk for chronic rejection without a lung biopsy, researchers reported.

In what was characterized as a proof-of-concept study, researchers from the National Heart, Lung, and Blood Institute (NHLBI), Johns Hopkins School of Medicine, and several other institutions described how donor-derived cell-free DNA (%ddcfDNA) characterized “post-transplantation ...

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First baby born to woman with uterus transplanted from deceased donor

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For the first time, a baby has been born to a woman who received a uterus transplant from a deceased donor, according to Hospital das Clínicas at the University of São Paulo School of Medicine in Brazil.

The Brazilian team followed protocols established by Dr. Mats Brännström and his team at the University of Gothenburg in Sweden, where the first successful uterus transplant, that one from a living donor, was performed in 2013. That recipient mother gave birth in 2014.

The donor, a 45-year-old ...

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Researchers look to drones as pathway to increase organ utilization

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University of Maryland researchers recently reported an initial investigation of drone-based organ transportation as a potential pathway towards expanding the donor organ pool.

To monitor the organ, researchers developed new technologies that provided the real-time organ status using a wireless biosensor combined with an organ global positioning system. Fourteen drone organ missions were performed.

Temperatures remained stable and low (2.5 °C). Pressure changes (0.37–0.86 kPa) correlated with increased altitude. Drone travel was associated with less vibration (less than 0.5 ...

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Penn Medicine Holds Virtual Classes for Transplant Candidates

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Penn Medicine runs one of the preeminent medical programs in the U.S. their hospitals are routinely ranked among the top 10 in the country. One reason might be that their transplant patients get a healthy dose of education before even getting on to a list.

Both transplant candidates and their caregivers are required to take an online course on the procedure before they can be considered. To improve convenience, Penn Medicine lung transplant nurse coordinator Daniel Miller developed a live online ...

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UT Southwestern demonstrates efficacy of portable donor liver system

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UT Southwestern announced its participation in the Liver PROJECT trial of a portable system designed to keep livers warm and blood circulating prior to liver transplantation, according to a press release.

“It’s like a virtual transplant,” Malcolm MacConmara, MD, from UT Southwestern’s department of surgery and lead researcher of the Liver PROTECT study, said in the release. “By putting the liver on the machine, we can truly approximate the conditions of the body. We provide oxygen, blood and nutrition to the liver and watch how ...

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Redefining the Donation Conversation in New #BeTheGift Campaign

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Signing up to be an organ donor means thinking about what happens after you die, which can be uncomfortable, so DCI Donor Services is appealing to potential donors differently.

“We thought what we had to do was battle these myths and misunderstandings about organ and tissue donation,” said Michael Ashmore, communications director at DCI. “As it turns out, when we started talking about this campaign, all these myths are such a small percentage of why people don’t do it. People just ...

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Hepatitis C-positive Heart Transplants: Safer After All?

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As of July 5, 2018, there are 3,960 people in the United States on the waitlist for a heart transplant. That’s only a fraction of the 114,554 people who need organ transplants. There is a great need for organ donations, and physicians at the University of Washington Medical Center have initiated a protocol to help with that.

The UW heart transplant team, led by Dr. Jason Smith, the associate surgical director of heart transplantation and a cardiac surgeon, plans to transplant hearts from ...

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A Dream Starting to Come True: Wearable Kidneys

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Without a transplant, patients with kidney failure need dialysis to stay alive. Dialysis does a good job of cleaning the blood and removing extra fluid, but it takes a lot of time and can hurt a patient’s quality of life. Since the 1970s, doctors have been trying to make a dialysis machine that patients can wear. The hope has always been to free patients from a huge machine that keeps them tied down. But there were no parts small and ...

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Hepatitis C positive lungs safely transplanted to patients

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Lungs from donors who had hepatitis C have been successfully transplanted into 10 patients at Toronto General Hospital (TG).

All patients have recovered from their transplant surgery. Eight of them have already tested negative for the virus and the last two patients have recently started taking the drug regimen.

The transplants are part of a clinical trial that is the first to assess the safety of transplanting hepatitis positive organs to non-infected patients using the ex vivo technology. Developed at TG in 2008, the Toronto Ex Vivo ...

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