German scientists develop new nuclear medicine test to identify kidney transplant infection

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German scientists have developed a novel nuclear medicine test that can determine whether a kidney transplant patient has developed infection in the transplanted tissue. The study, which utilizes positron emission tomography/magnetic resonance imaging (PET/MRI), is presented in the December issue of The Journal of Nuclear Medicine.

Complicated urinary tract infections (UTIs) occur frequently in patients after kidney transplantation due to suppression of the immune system and may lead to transplant failure or sepsis. Detecting the source and extent of infection–especially whether the ...

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Penn Medicine launches first clinical trial for uterine transplant in the northeast

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PHILADELPHIA – Penn Medicine will conduct the Northeast’s first clinical trial of uterine transplants, to provide women with Uterine Factor Infertility (UFI) – an irreversible form of female infertility that affects as many as 5 percent of women worldwide and 50,000 women in the United States – with a new path to parenthood. A woman with UFI cannot carry a pregnancy either because she was born without a uterus, has had the organ surgically removed, or has a uterus that ...

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C-Suite Snapshot Series: Legal Aspects of A Registered Donor

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The Alliance is delighted to share the Fall 2017 edition of the hospital C-Suite Snapshot, a one-page e-publication focused on organ, eye, and tissue donation-related topics relevant to hospital administrators. This edition is focused on legal aspects of a registered donor, and what hospital administrators need to know.

Click here to read the latest issue, or visit https://organdonationalliance.org/csuite:

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High-speed jet to quicken organ transplant delivery

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Donations of vital human organs like hearts and livers will happen faster and more reliably for patients in and around Utah. That’s because of a recently acquired high-speed jet at Intermountain Life Flight.

The new aircraft is a Cessna CJ4. It’s filled with medical equipment and storage, kind of like a flying ICU. Life Flight bought the jet last year and recently finished outfitting it for organ transport.

Tracy Schmidt is the executive director of Intermountain Donor Services, the group that retrieves donated organs ...

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Joint Statement of the President’s Roundtable: October 23, 2017

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The following statement was issued by the President’s Roundtable on October 23, 2017:

The Presidents’ Roundtable is a partnership among the presidents and chief staff officers of the American Society for Histocompatibility and Immunogenetics (ASHI), Association of Organ Procurement Organizations (AOPO), American Society of Transplantation (AST), American Society of Transplant Surgeons (ASTS), NATCO, The Organization for Transplant Professionals, The Organ Donation and Transplantation Alliance (The Alliance) and the United Network for Organ Sharing (UNOS) designed to promote collaboration and advance the ...

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Education Corner – Brain Death Pronouncement

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Brain Death Pronouncement

Summary Points:

  • State legislation provides guidance on requirements for brain death determination.
  • The AAN provides best practice recommendations for the determination process.
  • Ancillary tests are not required by legislation, but should be utilized only when the clinical examination cannot be fully performed or confounders cannot be corrected.
  • Apnea testing is not an ancillary test – it is an essential part of the clinical evaluation, testing brainstem function.

Best practices in pronouncing brain death include following state legislative requirements and the American ...

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DAAs prove effective for HCV-infected heart transplant patients

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Direct-acting antiviral (DAA) drugs proved safe and effective for hepatitis C (HCV) patients who had undergone heart transplants, according to new research.

Jia-Horng Kao, MD, PhD, FAASLD, and a team from the National Taiwan University Hospital in Taipei, found that 12 individuals given sofosbuvir combined with ledipasvir (Harvoni) or sofosbuvir (Sovaldi) combined with daclatasvir (Daklinza) achieved a sustained virologic response rate of 100% after 12 weeks.

Interferon-free DAAs have shown excellent efficacy and safety for ordinary patients with chronic HCV infection, the researchers ...

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High-dose influenza vaccine better for solid organ transplant recipients

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A high-dose influenza vaccine is preferable to a standard-dose vaccine in adult solid organ transplant recipients, according to study findings presented at IDWeek.

Yoichiro Natori, MD, clinical fellow of transplant infectious diseases at the University Health Network, University of Toronto, summarized results showing that a high-dose influenza vaccine (Fluzone High-Dose, Sanofi Pasteur; HD) demonstrated “significantly better immunogenicity” when compared with a standard-dose vaccine (Fluviral, GlaxoSmithKline; SD) in adult solid organ transplant recipients.

Transplant recipients are on lifelong immunosuppression and a particularly ...

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In some patients, hepatitis C best treated after transplant

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Direct-acting antiviral drugs can eradicate the hepatitis C virus, even in patients with advanced liver decompensation. But their outcomes may be better if treatment occurs after transplant, according to a recent study looking at this issue.

The goal of the study was to determine when life expectancy was improved with DAA treatment, before or after liver transplant. One reason these may differ is that the trade-off for improved liver function with early treatment is the risk for delay—or even delisting for ...

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UNOS searches for a fairer way to distribute donor livers

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More than 16,000 Americans are waiting for a liver transplant because of conditions such as hepatitis, cancer or cirrhosis. But only about 7,000 livers are donated each year. Most patients know their odds aren’t great.

And their chances also vary based on where they live.

“In some areas of the country, patients have to wait a lot longer than in other areas,” says Julie Heimbach, a transplant surgeon at the Mayo Clinic. “They have to get much sicker before they can access a liver ...

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