How first “kidney vouchers” led to 25 lifesaving transplants

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In 2014 a former judge from San Diego County approached the UCLA Kidney Transplant Program with an unusual request: If the judge donated a kidney to a stranger now, could his then 4-year-old grandson, who suffered from chronic kidney disease, receive priority for a future kidney transplant if needed later in life?

The suggestion from Howard Broadman, then 64 years old, initiated the kidney “voucher” program, an innovative system allowing living donors to donate a kidney now, or at some time in the ...

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Selena Gomez reveals she received a kidney transplant

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Selena Gomez took to Instagram this morning to reveal that she received the ultimate gift of life from her best friend, Francia Raisa. The actress and award-winning artist announced she received a kidney transplant over the summer due to complications from Lupus, an autoimmune disease that causes harm to organs and tissues. She said, “It was what I needed to do for my overall health.”

Although the leading causes of chronic kidney disease are mainly diabetes or high blood pressure, other related conditions, such ...

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World’s First 3-D Printed Tibia Transplanted

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Surgeons in Australia have successfully performed a world-first transplant surgery, installing a 3D printed tibia into the leg of Reuben Lichter, who faced losing his leg above the knee to amputation. The 3D printed tibia was wrapped in blood vessels and leg tissue from both of his legs. Just over two weeks ago, in the last in a series of five surgeries, the procedure was declared a success. For the next nine months at least, the doctors hope to observe ...

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Heat therapy may aid treatment of cancer, organ transplants and autoimmune disease

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Heat therapy may be a promising treatment in the fight against cancer, autoimmune problems and efforts to avoid organ rejection in transplant patients, according to researchers at the University of Kentucky. The research team exposed colorectal cancer cells and T-cells—immune cells that fight disease—to temperatures lower (hypothermic) and higher (hyperthermic) than normal body temperatures. They observed the effects of these temperature changes on the energy production (bioenergetics) in both cell types. They will present their findings at the American Physiological ...

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Education Corner – Developing Advances in Organ Transplantation: Organ Banking – What is it?

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Developing Advances in Organ Transplantation: Organ Banking – What is it?

A New World?

Imagine a world where no one who needs an organ transplant has to wait for an organ to become available. A transplant in this new world would be a scheduled surgery. Families who want the donation process to occur quickly could easily be accommodated, as the organs can be recovered and banked until the right ...

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Donor intervention strategies have potential to increase number of transplantable organs

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In a recent article published in The Hastings Center Report, the authors assert that “interventional research on deceased organ donors and donor organs prior to transplant holds the promise of reducing the number of patients who die waiting for an organ by expanding the pool of transplantable organs and improving transplant outcomes.” The authors posit, “one of the key challenges researchers face is an assumption that someone who receives an organ that was part of an interventional research ...

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Virtual Journal Club: To Presume Consent or Not to Presume Consent?

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To Presume Consent or Not to Presume Consent? What does the data show? Comparing Organ Donation Rates in “Opt-In” vs. “Opt-Out” Systems

Thomas Mone, MS; CEO OneLegacy, Los Angeles, 2017

Introduction:
Almost every day, somewhere in the world, a news headline calls for countries to adopt Opt-Out organ donation policies. Accompanying the call-to-action, is often a heart-wrenching story of a young child desperately awaiting a lifesaving transplant, or recipients seeking the help of their legislators to modify laws ...

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Nanoparticles “trick” body into accepting organ transplants

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Using nanoparticles, Yale researchers have developed a drug-delivery system that could reduce organ transplant complications by hiding the donated tissue from the recipient’s immune system.

About 25,000 organ transplants are performed in the U.S. each year. Despite significant advances in the field, short-term and long-term organ rejection still poses a risk (rejection rates vary depending on the type of organ). The risk of rejection is even higher when the donor is deceased, due to organ damage.

T cells, the white blood cells ...

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Novel procedure improves kidney transplant success

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A new treatment might open the door for more patients with advanced kidney disease to get a transplant, a preliminary study suggests.

Of the 100,000-plus Americans waiting for a donor kidney, about one-third are “sensitized,” said Dr. Robert Montgomery, director of the Transplant Institute at NYU Langone in New York City.

Those patients face a tough situation: They harbor immune system antibodies that are primed to attack a donor organ.

The antibodies can form when a person is ...

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Liver transplant patients benefit from moderate, high intensity exercise

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Combined resistance and aerobic training at moderate to high intensity improved aerobic capacity, maximal strength and health-related quality of life in liver transplant patients, according to a recently published study.

“An adequate recovery together with an improvement in the patient fitness and indirect understanding of the relevance of exercise in [health-related quality of life] may result in the long-term in a reduced incidence of metabolic complications,” Diego Moya-Nájera, MsC, from the University of Valencia, Spain, and colleagues wrote. “Indeed, diseases associated with metabolic ...

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