The Organ Donation and Transplantation Alliance, commonly known as the Alliance, is a non-profit, independent organization, incorporated in 2006 for the purpose of ensuring a continued national commitment to increasing organ availability and eliminating deaths on transplant wait lists. The first formal organizational meeting of the Organ Donation and Transplantation Alliance Steering Committee took place in Los Angeles, CA on February 21, 2006.

The initial mission of the Alliance was to expand and extend the work of the Organ Donation National Breakthrough Collaborative to achieve and maintain a national conversion rate of 75% and an organ transplant rate of 3.75 organs per donor. The Alliance was fully incorporated in the District of Columbia on June 13, 2006, with initial funding coming from generous financial donations of approximately 35 organ procurement organizations and AOPO.  From 2006 to 2010, the Alliance partnered with the Health Resources Services Administration (HRSA) to provide meetings that focused on the specific relationship between the critical care intensivist and the OPO community.